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Barcoding both strands of each DNA molecule let researchers find mutations carried by fewer than 1 in 100,000 molecules.
SaferSeqS introduces identical molecular barcodes into the Watson and Crick strands of template molecules and enriches targets by strand-specific PCR. It detects variants at frequencies below 1 in 100,000 DNA template molecules with a background mutation rate below 5 x 10^-7 mutants per base pair, can evaluate one or several amplicons, assesses limited quantities of cell-free DNA with high recovery of both strands, and reduces the error rate of existing PCR-based barcoding by more than 100-fold.
Error is no longer what stops a blood test reading one rare molecule; how many molecules there are is.
Shares Nature Biotechnology, Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Nature Biotechnology, Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Next-generation sequencing (NGS), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
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