Irving L. Weissman
Isolated the first blood stem cells and discovered the 'don't eat me' signal CD47 on cancer cells.
Stem cell biologist who first purified hematopoietic stem cells, defined leukaemia stem cells, and identified CD47 as a macrophage checkpoint, leading to magrolimab and the innate checkpoint field.
| Title | Journal | Year |
|---|---|---|
| CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis | Cell | 2009 |
| The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors | Proceedings of the National Academy of Sciences of the United States of America | 2012 |
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not linked directly; found by shared links- TermTumour-associated macrophages (TAMs)
Shares Magrolimab, CD47.
- PersonRonald Levy
Shares Stanford Health Care / Stanford Cancer Institute, Diffuse large B-cell lymphoma.
- IdeaBispecific antibodies that engage macrophages instead of T cells
Shares Magrolimab, CD47.
- PersonAsh A. Alizadeh
Shares Stanford Health Care / Stanford Cancer Institute, Diffuse large B-cell lymphoma.
- CompanyNkarta
Shares Acute myeloid leukaemia, Diffuse large B-cell lymphoma.
- PersonStephen J. Forman
Shares Acute myeloid leukaemia, Diffuse large B-cell lymphoma.
- InstitutionHamad Medical Corporation / National Center for Cancer Care and Research
Shares Acute myeloid leukaemia, Diffuse large B-cell lymphoma.
- PathwayHedgehog signalling
Shares Stanford Health Care / Stanford Cancer Institute, Acute myeloid leukaemia.