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Living with cancer· Appointment prep

Appointment sheet: Osteosarcoma

One page to bring and write on: your details, the questions for Osteosarcoma plus your own, the words you may hear, what to bring, the treatments the standard of care names, and room for the answers and agreed next steps. What you type stays in this browser. Print it or save it as a PDF. New to all this? Start with the first 60 days. Orientation, not medical advice.

Tick the questions to print

All of this cancer's questions start ticked. Untick what does not apply; ticks are kept in this browser. .

Your own questions

Shared with the prep pack, so questions you add there appear here too.

Print or save as PDF

Use (or Ctrl+P, Cmd+P on a Mac). To keep a copy, choose Save as PDF as the destination in the print dialog. Only the sheet prints; the controls stay on screen. Your typed notes print where you typed them; empty fields print as ruled lines to write on.

Appointment sheet

Osteosarcoma

Prepared with OnCo (onco.cc/prep/osteosarcoma/). Orientation, not medical advice; your team knows your case.

My details

Name
Date of appointment
Hospital and clinician
Who is coming with me

What I know, what is unclear, changes to discuss

Saved in this browser
What I know so far
What is unclear to me
Changes since last time

My questions

17 on the sheet
Newly diagnosed
  1. 1.What is my exact diagnosis, stage, and grade, and which tests established them?
  2. 2.Which biomarkers have been tested on my tumour (for example Histologic necrosis after neoadjuvant chemotherapy, Alkaline phosphatase and LDH, Metastases at diagnosis, Germline TP53 / RB1 / RECQL4, GD2, HER2, B7-H3 expression), and what were the results?
  3. 3.Which subtype is my cancer, and does that change the recommended treatment?
  4. 4.Is germline (inherited) genetic testing recommended for me or my family?
Localised high-grade
  1. 5.For my situation (localised high-grade), which of the standard options do you recommend and why?
  2. 6.Am I a candidate for Methotrexate, Doxorubicin, Cisplatin or related drugs, and what side effects should I expect?
Metastatic at diagnosis
  1. 7.For my situation (metastatic at diagnosis), which of the standard options do you recommend and why?
  2. 8.Am I a candidate for Methotrexate, Doxorubicin, Cisplatin or related drugs, and what side effects should I expect?
Relapsed
  1. 9.For my situation (relapsed), which of the standard options do you recommend and why?
  2. 10.Am I a candidate for Ifosfamide, Etoposide, Regorafenib or related drugs, and what side effects should I expect?
Unresectable / axial
  1. 11.For my situation (unresectable / axial), which of the standard options do you recommend and why?
  2. 12.Am I a candidate for Radium-223 dichloride, and what side effects should I expect?
Any stage
  1. 13.Are there clinical trials I could join, for example of Regorafenib, Cabozantinib, CAR-T cell therapy, Radium-223 dichloride?
  2. 14.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
  3. 15.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
  4. 16.I read that “No survival improvement since the 1980s; metastatic and relapsed disease ~20-30% survival”. How does that affect my plan?
  5. 17.I read that “No recurrent druggable driver; genomic chaos”. How does that affect my plan?

The words I may hear

  • Limb-salvage surgery: Removing a bone or soft-tissue sarcoma while keeping the arm or leg, rebuilding the bone with a metal endoprosthesis or a graft.
  • FNCLCC grade (soft-tissue sarcoma): The FNCLCC grade is a 1-to-3 score for soft-tissue sarcomas based on how abnormal, how fast-dividing, and how much dead tissue the tumour shows; grade drives whether chemotherapy is considered.
  • Li-Fraumeni syndrome (germline TP53): Li-Fraumeni syndrome is an inherited fault in the TP53 gene giving a lifetime cancer risk near 100% in women and ~75% in men, with sarcomas, breast cancer, brain tumours, adrenal cancer and leukaemias often in childhood.
  • Adolescent and young adult (AYA) oncology: Cancer in people aged 15-39, about 90,000 US cases a year, with a distinct mix of cancers, slower survival improvement than children or older adults, and specific needs: fertility, education and work, psychosocial support and trial access.

Tests and results to bring

Metastatic at diagnosis: Same chemotherapy with resection of all metastases (thoracotomy) when feasible; survival ~25-30%.

Biomarker results to ask for: Histologic necrosis after neoadjuvant chemotherapy (≥90% good response), Alkaline phosphatase and LDH, Metastases at diagnosis (lung, bone), Germline TP53 / RB1 / RECQL4, GD2, HER2, B7-H3 expression (trial eligibility), ctDNA copy-number burden (prognostic, emerging).

Scans and tests linked to this cancer: X-ray radiography and fluoroscopy, Biology-guided radiotherapy (RefleXion X1, SCINTIX), Methylation classifier for sarcomas.

Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.

The treatments I may be offered

From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.

Answers and next steps

Saved in this browser
What I was told
Agreed next steps, dates and who to call