APBB1IP
APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.79, affected pathway 0.97, animal model 0.50, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE.
- 3 · How drugs use it
No product in this corpus aims at APBB1IP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:17379 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z5R6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000077420 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Biology
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion. Location: Cell membrane; Cell projection, lamellipodium; Cell junction, focal adhesion; Cytoplasm, cytoskeleton (UniProt). Locus 10p12.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"APBB1IP" OR ABSTRACT:"APBB1IP" OR TITLE:"amyloid beta precursor protein binding family B member 1 interacting protein" OR ABSTRACT:"amyloid beta precursor protein binding family B member 1 interacting protein" OR TITLE:"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein" OR ABSTRACT:"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein" OR TITLE:"RARP1" OR ABSTRACT:"RARP1" OR TITLE:"PREL1" OR ABSTRACT:"PREL1" OR TITLE:"INAG1" OR ABSTRACT:"INAG1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APBB1IP, not a curated reading list.