ATXN7
ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Overview
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex.
CIViC holds 4 clinical evidence items and 0 assertions across 5 variants.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
- 1 · What it is
ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation.
- 3 · How drugs use it
No product in this corpus aims at ATXN7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:10560 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15265 (protein name, function text, keywords and locations (REST API)); CIViC gene ATXN7 (4 evidence items, 0 assertions, 5 variants; diseases: Thyroid Cancer, Thyroid Gland Carcinoma (GraphQL API, CC0))
Biology
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilisation. Involved in neurodegeneration. Location: Nucleus; Nucleus, nucleolus; Nucleus matrix; Cytoplasm, cytoskeleton (UniProt). Locus 3p14.1 (HGNC).
- Thyroid cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ATXN7" OR ABSTRACT:"ATXN7" OR TITLE:"ataxin 7" OR ABSTRACT:"ataxin 7" OR TITLE:"Ataxin-7" OR ABSTRACT:"Ataxin-7" OR TITLE:"OPCA3" OR ABSTRACT:"OPCA3" OR TITLE:"ADCAII" OR ABSTRACT:"ADCAII" OR TITLE:"SGF73" OR ABSTRACT:"SGF73") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATXN7, not a curated reading list.
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