PAX8
PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Overview
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.37, literature 0.99, genetic association 0.50, somatic mutation 0.95, animal model 0.53).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
- 1 · What it is
PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
- 2 · What goes wrong in cancer
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at PAX8 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:8622 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06710 (protein name, function text, keywords and locations (REST API)); CIViC gene PAX8 (1 evidence items, 0 assertions, 1 variants; diseases: Female Reproductive Organ Cancer (GraphQL API, CC0)); Open Targets ENSG00000125618 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: thyroid cancer 0.61 (GraphQL API, CC0))
Biology
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Location: Nucleus (UniProt). Locus 2q14.1 (HGNC).
- Thyroid cancer: Open Targets association 0.61 with thyroid cancer (MONDO_0002108)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Female Reproductive Organ Cancer.
Latest papers
topQuery for this target: (TITLE:"PAX8" OR ABSTRACT:"PAX8" OR TITLE:"paired box 8" OR ABSTRACT:"paired box 8" OR TITLE:"Paired box protein Pax-8" OR ABSTRACT:"Paired box protein Pax-8" OR TITLE:"PAX-8" OR ABSTRACT:"PAX-8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX8, not a curated reading list.
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