CTAG1B
CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
Overview
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B".
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Letetresgene Autoleucel. In OnCo, 1 product record names it (Letetresgene autoleucel).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
- 1 · What it is
CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.
- 2 · What goes wrong in cancer
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B". Location: Cytoplasm (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CTAG1B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2491 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78358 (protein name, function text, keywords and locations (REST API)); CIViC gene CTAG1B (2 evidence items, 0 assertions, 2 variants; diseases: Multiple Myeloma, Myxoid Liposarcoma (GraphQL API, CC0))
Biology
UniProt has no function text for P78358; HGNC names it "cancer/testis antigen 1B". Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).
- Multiple myeloma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Myxoid Liposarcoma.
Latest papers
topQuery for this target: (TITLE:"CTAG1B" OR ABSTRACT:"CTAG1B" OR TITLE:"cancer/testis antigen 1B" OR ABSTRACT:"cancer/testis antigen 1B" OR TITLE:"Cancer/testis antigen 1" OR ABSTRACT:"Cancer/testis antigen 1" OR TITLE:"NY-ESO-1" OR ABSTRACT:"NY-ESO-1" OR TITLE:"LAGE2B" OR ABSTRACT:"LAGE2B" OR TITLE:"LAGE2A" OR ABSTRACT:"LAGE2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTAG1B, not a curated reading list.