FANCC
FANCC (Fanconi anaemia group C protein) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Leukaemia, Pancreatic ductal adenocarcinoma and 5 more.
Overview
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine, Mitomycin, Cisplatin and Chlorambucil and others. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes genetic literature 0.85, affected pathway 0.76, literature 0.89, genetic association 0.68, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FANCC (Fanconi anaemia group C protein) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Leukaemia, Pancreatic ductal adenocarcinoma and 5 more.
- 1 · What it is
FANCC (Fanconi anaemia group C protein) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Leukaemia, Pancreatic ductal adenocarcinoma and 5 more.
- 2 · What goes wrong in cancer
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
- 3 · How drugs use it
No product in this corpus aims at FANCC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3584 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q00597 (protein name, function text, keywords and locations (REST API)); CIViC gene FANCC (1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer (GraphQL API, CC0)); Open Targets ENSG00000158169 (association with cancer (MONDO_0004992) 0.80; per-cancer scores at or above 0.5: colorectal cancer 0.56, ovarian cancer 0.56, acute myeloid leukaemia 0.54, myelodysplastic syndrome 0.51, myeloproliferative neoplasm 0.54, breast cancer 0.65 (GraphQL API, CC0))
Biology
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Location: Nucleus; Cytoplasm (UniProt). Locus 9q22.32 (HGNC).
- Breast cancer: Open Targets association 0.65 with breast cancer (MONDO_0007254)
- Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059)
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
- Ovarian cancer: Open Targets association 0.56 with ovarian cancer (MONDO_0008170)
- Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)
- Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FANCC" OR ABSTRACT:"FANCC" OR TITLE:"FA complementation group C" OR ABSTRACT:"FA complementation group C" OR TITLE:"Fanconi anemia group C protein" OR ABSTRACT:"Fanconi anemia group C protein" OR TITLE:"FA3" OR ABSTRACT:"FA3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCC, not a curated reading list.
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