FANCG
FANCG (Fanconi anaemia group G protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Colorectal cancer and 2 more.
Overview
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.83, literature 0.90, genetic association 0.60, somatic mutation 0.96, animal model 0.35).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FANCG (Fanconi anaemia group G protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Colorectal cancer and 2 more.
- 1 · What it is
FANCG (Fanconi anaemia group G protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Colorectal cancer and 2 more.
- 2 · What goes wrong in cancer
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
- 3 · How drugs use it
No product in this corpus aims at FANCG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:3588 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15287 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000221829 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.52, acute myeloid leukaemia 0.54, myeloproliferative neoplasm 0.54, lung cancer 0.51, leukaemia 0.62 (GraphQL API, CC0))
Biology
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene. Location: Nucleus; Cytoplasm (UniProt). Locus 9p13.3 (HGNC).
- Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)
- Acute myeloid leukaemia: Open Targets association 0.54 with acute myeloid leukaemia (MONDO_0018874)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FANCG" OR ABSTRACT:"FANCG" OR TITLE:"FA complementation group G" OR ABSTRACT:"FA complementation group G" OR TITLE:"Fanconi anemia group G protein" OR ABSTRACT:"Fanconi anemia group G protein" OR TITLE:"XRCC9" OR ABSTRACT:"XRCC9") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCG, not a curated reading list.
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