FES

aka FES proto-oncogene, tyrosine kinase, Tyrosine-protein kinase Fes/Fps

FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.68, animal model 0.43, genetic association 0.47, somatic mutation 0.97). In OnCo, 1 product record names it (Fluoroestradiol F-18 (FES PET)).

FES: what it is and how drugs act on it · animated schematic, not to scale

Target · the protein and the cell it sits on
Drug · antibody, small molecule, cell or radioligand
Effect · signal, damage or kill

In plain words · FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.

1 · What it is
FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.
2 · What goes wrong in cancer
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading.
3 · How drugs use it
No product in this corpus aims at FES yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.

Full dossier: hotspots, trials, resistance, assays, models, open questions →

Evidence: Association only All cancer genes by role →

External identifiers

FESHGNCEnsemblUniProtAlphaFold DBOpen TargetsCIViCOncoKBCOSMICcBioPortalDepMapHuman Protein AtlasNCBI GeneOMIM

Sources: HGNC HGNC:3657 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07332 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182511 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.50, skin cancer 0.53, leukaemia 0.52 (GraphQL API, CC0))

Biology

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signalling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signalling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell membrane; Cytoplasmic vesicle (UniProt). Locus 15q26.1 (HGNC).

Where it is found

Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898)
Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
Colorectal cancer: Open Targets association 0.50 with colorectal cancer (MONDO_0005575)

Class

kinase · FES

Identifiers

HGNC HGNC:3657Ensembl ENSG00000182511UniProt P07332NCBI Gene 2242

Notes

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Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
Prevalence not recorded: none of the sources gives a positivity rate.