ERCC4
ERCC4 (DNA repair endonuclease XPF) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Skin cancer, Myeloproliferative neoplasms and 4 more.
Overview
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Immune Checkpoint Inhibitor. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.61, literature 0.98, genetic association 0.63, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ERCC4 (DNA repair endonuclease XPF) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Skin cancer, Myeloproliferative neoplasms and 4 more.
- 1 · What it is
ERCC4 (DNA repair endonuclease XPF) is an enzyme. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Leukaemia, Skin cancer, Myeloproliferative neoplasms and 4 more.
- 2 · What goes wrong in cancer
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair.
- 3 · How drugs use it
No product in this corpus aims at ERCC4 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:3436 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92889 (protein name, function text, keywords and locations (REST API)); CIViC gene ERCC4 (3 evidence items, 0 assertions, 1 variants; diseases: Melanoma, Lung Non-small Cell Carcinoma, Cancer (GraphQL API, CC0)); Open Targets ENSG00000175595 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: colorectal cancer 0.53, melanoma 0.54, acute myeloid leukaemia 0.53, skin cancer 0.55, myeloproliferative neoplasm 0.54, leukaemia 0.60 (GraphQL API, CC0))
Biology
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. Location: Nucleus; Chromosome (UniProt). Locus 16p13.12 (HGNC).
- Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076)
- Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)
- Melanoma: Open Targets association 0.54 with melanoma (MONDO_0005105); CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ERCC4" OR ABSTRACT:"ERCC4" OR TITLE:"ERCC excision repair 4, endonuclease catalytic subunit" OR ABSTRACT:"ERCC excision repair 4, endonuclease catalytic subunit" OR TITLE:"DNA repair endonuclease XPF" OR ABSTRACT:"DNA repair endonuclease XPF" OR TITLE:"RAD1" OR ABSTRACT:"RAD1" OR TITLE:"FANCQ" OR ABSTRACT:"FANCQ") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERCC4, not a curated reading list.
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