GATA1
GATA1 (Erythroid transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Skin cancer and 1 more.
Overview
Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.79 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.32, literature 0.96, genetic association 0.29, somatic mutation 0.94, animal model 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GATA1 (Erythroid transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Skin cancer and 1 more.
- 1 · What it is
GATA1 (Erythroid transcription factor) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Skin cancer and 1 more.
- 2 · What goes wrong in cancer
Transcriptional activator or repressor which serves as a general switch factor for erythroid development.
- 3 · How drugs use it
No product in this corpus aims at GATA1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:4170 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15976 (protein name, function text, keywords and locations (REST API)); CIViC gene GATA1 (2 evidence items, 0 assertions, 2 variants; diseases: Myeloid Leukaemia Associated With Down Syndrome, Transient Myeloproliferative Syndrome (GraphQL API, CC0)); Open Targets ENSG00000102145 (association with cancer (MONDO_0004992) 0.79; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.69, skin cancer 0.55, myeloproliferative neoplasm 0.73, leukaemia 0.71 (GraphQL API, CC0))
Biology
Transcriptional activator or repressor which serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. Location: Nucleus (UniProt). Locus Xp11.23 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.73 with myeloproliferative neoplasm (MONDO_0020076)
- Leukaemia: Open Targets association 0.71 with leukaemia (MONDO_0005059)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Acute myeloid leukaemia: Open Targets association 0.69 with acute myeloid leukaemia (MONDO_0018874)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Myeloid Leukaemia Associated With Down Syndrome; Transient Myeloproliferative Syndrome.
Latest papers
topQuery for this target: (TITLE:"GATA1" OR ABSTRACT:"GATA1" OR TITLE:"GATA binding protein 1" OR ABSTRACT:"GATA binding protein 1" OR TITLE:"Erythroid transcription factor" OR ABSTRACT:"Erythroid transcription factor" OR TITLE:"ERYF1" OR ABSTRACT:"ERYF1" OR TITLE:"NFE1" OR ABSTRACT:"NFE1" OR TITLE:"GATA-1" OR ABSTRACT:"GATA-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GATA1, not a curated reading list.
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