FGF23
FGF23 (Fibroblast growth factor 23) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and an approved or late-stage drug is recorded against it.
Overview
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.98, animal model 0.53). In OnCo, 1 product record names it (Burosumab).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FGF23 (Fibroblast growth factor 23) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and an approved or late-stage drug is recorded against it.
- 1 · What it is
FGF23 (Fibroblast growth factor 23) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels.
- 3 · How drugs use it
No product in this corpus aims at FGF23 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Sources: HGNC HGNC:3680 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9GZV9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000118972 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Biology
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Location: Secreted (UniProt). Locus 12p13.32 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it; a membrane or secreted protein (UniProt keywords) that 1 antibody-based OnCo product name. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FGF23" OR ABSTRACT:"FGF23" OR TITLE:"fibroblast growth factor 23" OR ABSTRACT:"fibroblast growth factor 23" OR TITLE:"Fibroblast growth factor 23" OR ABSTRACT:"Fibroblast growth factor 23") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF23, not a curated reading list.