GAB1
GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.82, animal model 0.50, genetic association 0.14).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling.
- 3 · How drugs use it
No product in this corpus aims at GAB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:4066 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13480 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109458 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signalling pathway. Locus 4q31.21 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"GAB1" OR ABSTRACT:"GAB1" OR TITLE:"GRB2 associated binding protein 1" OR ABSTRACT:"GRB2 associated binding protein 1" OR TITLE:"GRB2-associated-binding protein 1" OR ABSTRACT:"GRB2-associated-binding protein 1" OR TITLE:"DFNB26" OR ABSTRACT:"DFNB26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GAB1, not a curated reading list.