FRS2
FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.90, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways.
- 3 · How drugs use it
No product in this corpus aims at FRS2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:16971 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WU20 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000166225 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1. Location: Endomembrane system (UniProt). Locus 12q15 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"FRS2" OR ABSTRACT:"FRS2" OR TITLE:"fibroblast growth factor receptor substrate 2" OR ABSTRACT:"fibroblast growth factor receptor substrate 2" OR TITLE:"Fibroblast growth factor receptor substrate 2" OR ABSTRACT:"Fibroblast growth factor receptor substrate 2" OR TITLE:"SNT-1" OR ABSTRACT:"SNT-1" OR TITLE:"FRS2alpha" OR ABSTRACT:"FRS2alpha" OR TITLE:"SNT1" OR ABSTRACT:"SNT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FRS2, not a curated reading list.