HEY1
HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
Overview
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
- 1 · What it is
HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
- 2 · What goes wrong in cancer
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development.
- 3 · How drugs use it
No product in this corpus aims at HEY1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:4880 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5J3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164683 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: sarcoma 0.54, chondrosarcoma 0.52 (GraphQL API, CC0))
Biology
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
- Sarcomas: Open Targets association 0.54 with sarcoma (MONDO_0005089)
- Chondrosarcoma: Open Targets association 0.52 with chondrosarcoma (MONDO_0008977)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HEY1" OR ABSTRACT:"HEY1" OR TITLE:"hes related family bHLH transcription factor with YRPW motif 1" OR ABSTRACT:"hes related family bHLH transcription factor with YRPW motif 1" OR TITLE:"Hairy/enhancer-of-split related with YRPW motif protein 1" OR ABSTRACT:"Hairy/enhancer-of-split related with YRPW motif protein 1" OR TITLE:"HESR-1" OR ABSTRACT:"HESR-1" OR TITLE:"CHF2" OR ABSTRACT:"CHF2" OR TITLE:"HESR1" OR ABSTRACT:"HESR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HEY1, not a curated reading list.
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