HOXB13
HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
Overview
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.99, genetic association 0.86, somatic mutation 0.30, animal model 0.38). In OnCo, 1 product record names it (Breast Cancer Index).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
- 1 · What it is
HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
- 2 · What goes wrong in cancer
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
- 3 · How drugs use it
No product in this corpus aims at HOXB13 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:5112 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92826 (protein name, function text, keywords and locations (REST API)); CIViC gene HOXB13 (2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0)); Open Targets ENSG00000159184 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.52, prostate cancer 0.74 (GraphQL API, CC0))
Biology
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Location: Nucleus (UniProt). Locus 17q21.32 (HGNC).
- Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315); CIViC evidence names this disease
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"HOXB13" OR ABSTRACT:"HOXB13" OR TITLE:"homeobox B13" OR ABSTRACT:"homeobox B13" OR TITLE:"Homeobox protein Hox-B13" OR ABSTRACT:"Homeobox protein Hox-B13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXB13, not a curated reading list.