Breast Cancer Index
The only test designed to tell a woman who has finished five years of hormone therapy whether another five years is worth the side effects.
Overview
Breast Cancer Index (Biotheranostics, acquired by Hologic in 2021) is a laboratory-developed test for hormone-receptor-positive early breast cancer. Its HOXB13:IL17BR component was shown to predict benefit from extending endocrine therapy to 10 years in the MA.17, Trans-aTTom and IDEAL trial cohorts, and the ASCO and NCCN guidelines list it as the test for that decision; a prespecified NSABP B-42 analysis was less clear-cut. It also gives a late-recurrence risk (years 5 to 10). Medicare covers it. The test does not address the initial chemotherapy decision, which is the province of Oncotype DX, MammaPrint, Prosigna and EndoPredict.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Notes
top- What a result means: 'BCI (H/I) high' predicts that continuing hormone therapy past five years reduces recurrence; 'low' means the extra years add side effects without measurable benefit.
Latest papers
topQuery for this drug: (TITLE:"Breast Cancer Index" OR ABSTRACT:"Breast Cancer Index") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Breast Cancer Index, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductProsigna (PAM50)
Shares EndoPredict, Oncotype DX, RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer and the tag test.
- ProductMI Cancer Seek
Shares RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer and the tag test.
- ProductAfirma Genomic Sequencing Classifier
Shares RNA sequencing & expression profiling and the tag test.
- ProductCxbladder
Shares RNA sequencing & expression profiling and the tag test.
- ProductLunit INSIGHT MMG
Shares HR-positive / HER2-negative breast cancer and the tag test.
- ProductProFound AI (iCAD)
Shares HR-positive / HER2-negative breast cancer and the tag test.
- ProductOncotype DX Genomic Prostate Score
Shares RNA sequencing & expression profiling and the tag test.
- ProductProlaris
Shares RNA sequencing & expression profiling and the tag test.