Prolaris
A gene test on a prostate biopsy that estimates how aggressive the cancer is, to help decide between active surveillance and treatment.
Overview
Prolaris (Myriad Genetics) measures how fast tumour cells are dividing and reports a 10-year risk of dying from prostate cancer under conservative management and of metastasis after treatment. It is listed in NCCN guidelines as an option for men with low or favourable-intermediate risk disease considering active surveillance, is covered by Medicare, and validated in conservatively managed UK cohorts and US surgical series. Like Decipher and Oncotype DX GPS it refines, rather than replaces, PSA, Gleason grade and MRI; head-to-head comparisons are few and none of the three has randomised evidence that its use improves outcomes.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Notes
top- What a result means: a low score supports active surveillance; a high score in an otherwise low-risk cancer argues for treatment.
Latest papers
topQuery for this drug: (TITLE:"Prolaris" OR ABSTRACT:"Prolaris") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Prolaris, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductEndoPredict
Shares Myriad Genetics, RNA sequencing & expression profiling and the tag test.
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- ProductProsigna (PAM50)
Shares RNA sequencing & expression profiling and the tag test.