EndoPredict
A 12-gene test that combines gene activity with tumour size and lymph nodes to say whether hormone therapy alone is enough, and whether to continue it beyond five years.
Overview
EndoPredict (Sividon, acquired by Myriad Genetics in 2016) is CE-marked and validated in the ABCSG-6 and ABCSG-8 trial cohorts and in TransATAC, where EPclin identified a low-risk group with about 4% distant recurrence at 10 years on endocrine therapy alone and predicted late recurrence between years five and ten. NICE DG34 recommends it for guiding chemotherapy decisions in the NHS; it is offered in the US as a laboratory-developed test. Because it includes clinical variables, EPclin outperformed purely molecular scores in head-to-head comparisons on the TransATAC cohort.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Notes
top- What a result means: EPclin low means chemotherapy can safely be omitted and the case for extended hormone therapy is weak; EPclin high means the opposite.
Latest papers
topQuery for this drug: (TITLE:"EndoPredict" OR ABSTRACT:"EndoPredict") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EndoPredict, not a curated reading list.
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