PDGFB
PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
Overview
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta.
CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Imatinib Mesylate and Sorafenib Tosylate. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes affected pathway 0.61, literature 0.97, genetic association 0.20, somatic mutation 0.97, animal model 0.47).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
- 1 · What it is
PDGFB (Platelet-derived growth factor subunit B) is a gene. The public catalogues list it as a drug target, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas and Dermatofibrosarcoma protuberans.
- 2 · What goes wrong in cancer
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin.
- 3 · How drugs use it
No product in this corpus aims at PDGFB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:8800 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01127 (protein name, function text, keywords and locations (REST API)); CIViC gene PDGFB (3 evidence items, 0 assertions, 1 variants; diseases: Dermatofibrosarcoma Protuberans (GraphQL API, CC0)); Open Targets ENSG00000100311 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: sarcoma 0.63 (GraphQL API, CC0))
Biology
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signalling is modulated by the formation of heterodimers with PDGFA. Location: Secreted (UniProt). Locus 22q13.1 (HGNC).
- Sarcomas: Open Targets association 0.63 with sarcoma (MONDO_0005089)
- Dermatofibrosarcoma protuberans: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PDGFB" OR ABSTRACT:"PDGFB" OR TITLE:"platelet derived growth factor subunit B" OR ABSTRACT:"platelet derived growth factor subunit B" OR TITLE:"Platelet-derived growth factor subunit B" OR ABSTRACT:"Platelet-derived growth factor subunit B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDGFB, not a curated reading list.
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