PDGFRB
A growth receptor on connective-tissue and blood-vessel cells. Imatinib works in rare cancers driven by PDGFRB fusions, such as dermatofibrosarcoma protuberans and some chronic myeloid neoplasms with eosinophilia.
Overview
Platelet-derived growth factor receptor beta signals in fibroblasts, pericytes and smooth muscle. The COL1A1::PDGFB fusion of dermatofibrosarcoma protuberans drives the receptor through its own ligand, and PDGFRB rearrangements define a group of myeloid and lymphoid neoplasms with eosinophilia; both respond to imatinib, which inhibits PDGFRB alongside KIT, ABL1 and PDGFRA. Sunitinib, pazopanib and other multi-kinase inhibitors also block it, contributing to their anti-angiogenic effect through pericytes. In most solid tumours PDGFRB is a stromal rather than a tumour-cell target.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · A growth receptor on connective-tissue and blood-vessel cells. Imatinib works in rare cancers driven by PDGFRB fusions, such as dermatofibrosarcoma protuberans and some chronic myeloid neoplasms with eosinophilia.
- 1 · What it is
A growth receptor on connective-tissue and blood-vessel cells. Imatinib works in rare cancers driven by PDGFRB fusions, such as dermatofibrosarcoma protuberans and some chronic myeloid neoplasms with eosinophilia.
- 2 · What goes wrong in cancer
Receptor tyrosine kinase of mesenchymal cells and pericytes; oncogenic through fusions in dermatofibrosarcoma protuberans and myeloid neoplasms with eosinophilia.
- 3 · How drugs use it
No product in this corpus aims at PDGFRB yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Biology
Receptor tyrosine kinase of mesenchymal cells and pericytes; oncogenic through fusions in dermatofibrosarcoma protuberans and myeloid neoplasms with eosinophilia.
- Dermatofibrosarcoma protuberans (COL1A1::PDGFB)
- Myeloid or lymphoid neoplasms with PDGFRB rearrangement
- Tumour stroma and pericytes
Latest papers
topQuery for this target: (TITLE:"PDGFRB" OR ABSTRACT:"PDGFRB") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDGFRB, not a curated reading list.
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