PRPS1
PRPS1 (Ribose-phosphate pyrophosphokinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute lymphoblastic leukaemia.
Overview
Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
CIViC holds 45 clinical evidence items and 0 assertions across 21 variants, naming Mercaptopurine, Thioguanine, Daunorubicin and Cytarabine and others.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · PRPS1 (Ribose-phosphate pyrophosphokinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute lymphoblastic leukaemia.
- 1 · What it is
PRPS1 (Ribose-phosphate pyrophosphokinase 1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute lymphoblastic leukaemia.
- 2 · What goes wrong in cancer
Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Locus Xq22.3 (HGNC).
- 3 · How drugs use it
No product in this corpus aims at PRPS1 yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:9462 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P60891 (protein name, function text, keywords and locations (REST API)); CIViC gene PRPS1 (45 evidence items, 0 assertions, 21 variants; diseases: B-lymphoblastic Leukaemia/lymphoma (GraphQL API, CC0))
Biology
Catalyses the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Locus Xq22.3 (HGNC).
- Acute lymphoblastic leukaemia: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 7 therapies; CIViC holds 45 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"PRPS1" OR ABSTRACT:"PRPS1" OR TITLE:"phosphoribosyl pyrophosphate synthetase 1" OR ABSTRACT:"phosphoribosyl pyrophosphate synthetase 1" OR TITLE:"Ribose-phosphate pyrophosphokinase 1" OR ABSTRACT:"Ribose-phosphate pyrophosphokinase 1" OR TITLE:"CMTX5" OR ABSTRACT:"CMTX5" OR TITLE:"DFNX1" OR ABSTRACT:"DFNX1" OR TITLE:"PRS-I" OR ABSTRACT:"PRS-I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PRPS1, not a curated reading list.