RFX7
RFX7 (DNA-binding protein RFX7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Burkitt lymphoma.
Overview
Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.66, animal model 0.32, genetic association 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RFX7 (DNA-binding protein RFX7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Burkitt lymphoma.
- 1 · What it is
RFX7 (DNA-binding protein RFX7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Burkitt lymphoma.
- 2 · What goes wrong in cancer
Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5.
- 3 · How drugs use it
No product in this corpus aims at RFX7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:25777 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q2KHR2 (protein name, function text, keywords and locations (REST API)); CIViC gene RFX7 (1 evidence items, 0 assertions, 1 variants; diseases: Burkitt Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000181827 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0))
Biology
Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure. Location: Nucleus (UniProt). Locus 15q21.3 (HGNC).
- Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)
- Burkitt lymphoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RFX7" OR ABSTRACT:"RFX7" OR TITLE:"regulatory factor X7" OR ABSTRACT:"regulatory factor X7" OR TITLE:"DNA-binding protein RFX7" OR ABSTRACT:"DNA-binding protein RFX7" OR TITLE:"FLJ12994" OR ABSTRACT:"FLJ12994" OR TITLE:"RFXDC2" OR ABSTRACT:"RFXDC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RFX7, not a curated reading list.
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