RIT1
RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
Overview
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex.
CIViC holds 14 clinical evidence items and 0 assertions across 8 variants, naming Selumetinib and Pictilisib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
- 1 · What it is
RIT1 (GTP-binding protein Rit1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer and Non-small-cell lung cancer.
- 2 · What goes wrong in cancer
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation.
- 3 · How drugs use it
No product in this corpus aims at RIT1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:10023 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92963 (protein name, function text, keywords and locations (REST API)); CIViC gene RIT1 (14 evidence items, 0 assertions, 8 variants; diseases: Lung Adenocarcinoma, Endometrial Cancer (GraphQL API, CC0))
Biology
Plays a crucial role in coupling nerve growth factor (NGF) stimulation to the activation of both EPHB2 and MAPK14 signalling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signalling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Recognised by LZTR1, which mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Location: Cell membrane (UniProt). Locus 1q22 (HGNC).
- Endometrial cancer: CIViC evidence names this disease
- Non-small-cell lung cancer: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 14 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RIT1" OR ABSTRACT:"RIT1" OR TITLE:"Ras like without CAAX 1" OR ABSTRACT:"Ras like without CAAX 1" OR TITLE:"GTP-binding protein Rit1" OR ABSTRACT:"GTP-binding protein Rit1" OR TITLE:"ROC1" OR ABSTRACT:"ROC1" OR TITLE:"MGC125864" OR ABSTRACT:"MGC125864" OR TITLE:"MGC125865" OR ABSTRACT:"MGC125865") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RIT1, not a curated reading list.