RMI2
RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
Overview
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.87, genetic association 0.41, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
- 1 · What it is
RMI2 (RecQ-mediated genome instability protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Non-Hodgkin lymphoma, Breast cancer, Lung cancer and 1 more.
- 2 · What goes wrong in cancer
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover.
- 3 · How drugs use it
No product in this corpus aims at RMI2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:28349 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96E14 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000175643 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: diffuse large B-cell lymphoma 0.57, non-Hodgkin lymphoma 0.61, breast cancer 0.54, lung cancer 0.50 (GraphQL API, CC0))
Biology
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localisation, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. Location: Nucleus (UniProt). Locus 16p13.13 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)
- Diffuse large B-cell lymphoma: Open Targets association 0.57 with diffuse large B-cell lymphoma (MONDO_0018905)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"RMI2" OR ABSTRACT:"RMI2" OR TITLE:"RecQ mediated genome instability 2" OR ABSTRACT:"RecQ mediated genome instability 2" OR TITLE:"RecQ-mediated genome instability protein 2" OR ABSTRACT:"RecQ-mediated genome instability protein 2" OR TITLE:"MGC24665" OR ABSTRACT:"MGC24665" OR TITLE:"BLAP18" OR ABSTRACT:"BLAP18" OR TITLE:"C16orf75" OR ABSTRACT:"C16orf75") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RMI2, not a curated reading list.
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