SS18
SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Overview
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.21, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
- 1 · What it is
SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
- 2 · What goes wrong in cancer
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation.
- 3 · How drugs use it
No product in this corpus aims at SS18 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11340 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15532 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141380 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: sarcoma 0.61, synovial sarcoma 0.53 (GraphQL API, CC0))
Biology
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Location: Nucleus (UniProt). Locus 18q11.2 (HGNC).
- Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089)
- Synovial sarcoma: Open Targets association 0.53 with synovial sarcoma (MONDO_0010434)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SS18" OR ABSTRACT:"SS18" OR TITLE:"SS18 subunit of BAF chromatin remodeling complex" OR ABSTRACT:"SS18 subunit of BAF chromatin remodeling complex" OR TITLE:"SMARCL1" OR ABSTRACT:"SMARCL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SS18, not a curated reading list.
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