SSX2
SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Overview
Could act as a modulator of transcription.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
- 1 · What it is
SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
- 2 · What goes wrong in cancer
Could act as a modulator of transcription. Location: Nucleus (UniProt).
- 3 · How drugs use it
No product in this corpus aims at SSX2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:11336 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16385 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000241476 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: sarcoma 0.61, synovial sarcoma 0.53 (GraphQL API, CC0))
Biology
Could act as a modulator of transcription. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).
- Sarcomas: Open Targets association 0.61 with sarcoma (MONDO_0005089)
- Synovial sarcoma: Open Targets association 0.53 with synovial sarcoma (MONDO_0010434)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SSX2" OR ABSTRACT:"SSX2" OR TITLE:"SSX family member 2" OR ABSTRACT:"SSX family member 2" OR TITLE:"HOM-MEL-40" OR ABSTRACT:"HOM-MEL-40" OR TITLE:"HD21" OR ABSTRACT:"HD21" OR TITLE:"MGC3884" OR ABSTRACT:"MGC3884" OR TITLE:"MGC15364" OR ABSTRACT:"MGC15364") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SSX2, not a curated reading list.
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