SYK
SYK (Tyrosine-protein kinase SYK) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer, Skin cancer, Lung cancer and 4 more.
Overview
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signalling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Paclitaxel. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes clinical 0.50, literature 0.99, genetic association 0.38, somatic mutation 0.98, animal model 0.51). In OnCo, 1 product record names it (Fostamatinib).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · SYK (Tyrosine-protein kinase SYK) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer, Skin cancer, Lung cancer and 4 more.
- 1 · What it is
SYK (Tyrosine-protein kinase SYK) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Ovarian cancer, Skin cancer, Lung cancer and 4 more.
- 2 · What goes wrong in cancer
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR).
- 3 · How drugs use it
No product in this corpus aims at SYK yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
External identifiers
Sources: HGNC HGNC:11491 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P43405 (protein name, function text, keywords and locations (REST API)); CIViC gene SYK (1 evidence items, 0 assertions, 1 variants; diseases: Ovarian Cancer (GraphQL API, CC0)); Open Targets ENSG00000165025 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.54, melanoma 0.56, skin cancer 0.58, breast cancer 0.54, lung cancer 0.55, leukaemia 0.50 (GraphQL API, CC0))
Biology
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signalling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Location: Cell membrane; Cytoplasm, cytosol (UniProt). Locus 9q22.2 (HGNC).
- Ovarian cancer: CIViC evidence names this disease
- Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)
- Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)
- Leukaemia: Open Targets association 0.50 with leukaemia (MONDO_0005059)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.50; CIViC holds 1 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"SYK" OR ABSTRACT:"SYK" OR TITLE:"spleen associated tyrosine kinase" OR ABSTRACT:"spleen associated tyrosine kinase" OR TITLE:"Tyrosine-protein kinase SYK" OR ABSTRACT:"Tyrosine-protein kinase SYK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SYK, not a curated reading list.
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