TNFRSF10B
TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Overview
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, clinical 0.20, literature 0.98, genetic association 0.79, animal model 0.27).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 1 · What it is
TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
- 2 · What goes wrong in cancer
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor.
- 3 · How drugs use it
No product in this corpus aims at TNFRSF10B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11905 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14763 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000120889 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Biology
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Location: Membrane (UniProt). Locus 8p21.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.20. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TNFRSF10B" OR ABSTRACT:"TNFRSF10B" OR TITLE:"TNF receptor superfamily member 10b" OR ABSTRACT:"TNF receptor superfamily member 10b" OR TITLE:"Tumor necrosis factor receptor superfamily member 10B" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 10B" OR TITLE:"DR5" OR ABSTRACT:"DR5" OR TITLE:"KILLER" OR ABSTRACT:"KILLER" OR TITLE:"TRICK2A" OR ABSTRACT:"TRICK2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFRSF10B, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTNFSF10
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.
- TargetFAS
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.