TNFSF10
TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.25, genetic association 0.62).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis.
- 3 · How drugs use it
No product in this corpus aims at TNFSF10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:11925 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50591 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000121858 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Location: Cell membrane; Secreted (UniProt). Locus 3q26.31 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"TNFSF10" OR ABSTRACT:"TNFSF10" OR TITLE:"TNF superfamily member 10" OR ABSTRACT:"TNF superfamily member 10" OR TITLE:"Tumor necrosis factor ligand superfamily member 10" OR ABSTRACT:"Tumor necrosis factor ligand superfamily member 10" OR TITLE:"TRAIL" OR ABSTRACT:"TRAIL" OR TITLE:"Apo-2L" OR ABSTRACT:"Apo-2L" OR TITLE:"TL2" OR ABSTRACT:"TL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFSF10, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetTNFRSF10B
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.
- TargetFAS
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.