Thioredoxin reductase 1
Thioredoxin reductase keeps cells' antioxidant defences charged; arsenic trioxide, the drug that cures most acute promyelocytic leukaemia with ATRA, inhibits it as one of its several actions.
Overview
Thioredoxin reductase 1 is a selenium-containing enzyme that recycles thioredoxin, a small protein that keeps other proteins reduced and protects against oxidative stress. Many cancers over-express it to survive their own high oxidant load. Arsenic trioxide binds the selenocysteine in the enzyme's active site and inhibits it, adding oxidative stress to its direct degradation of the PML-RARA fusion protein in acute promyelocytic leukaemia. Gold compounds such as auranofin inhibit the same enzyme and are in trials for chronic lymphocytic leukaemia and ovarian cancer.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · Thioredoxin reductase keeps cells' antioxidant defences charged; arsenic trioxide, the drug that cures most acute promyelocytic leukaemia with ATRA, inhibits it as one of its several actions.
- 1 · What it is
Thioredoxin reductase keeps cells' antioxidant defences charged; arsenic trioxide, the drug that cures most acute promyelocytic leukaemia with ATRA, inhibits it as one of its several actions.
- 2 · What goes wrong in cancer
A cytosolic flavoenzyme that uses NADPH to reduce thioredoxin; it supports DNA synthesis through ribonucleotide reductase and buffers reactive oxygen species.
- 3 · How drugs use it
No product in this corpus aims at Thioredoxin reductase 1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Biology
A cytosolic flavoenzyme that uses NADPH to reduce thioredoxin; it supports DNA synthesis through ribonucleotide reductase and buffers reactive oxygen species.
- All cells, highest in tumours with high oxidative metabolism
- Acute promyelocytic leukaemia treated with arsenic trioxide
Latest papers
topQuery for this target: (TITLE:"Thioredoxin reductase 1" OR ABSTRACT:"Thioredoxin reductase 1" OR TITLE:"TXNRD1" OR ABSTRACT:"TXNRD1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Thioredoxin reductase 1, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetRetinoic acid receptor alpha (RARA)
Shares Arsenic trioxide, Acute myeloid leukaemia.
- PersonSaijuan Chen
Shares Arsenic trioxide, Acute myeloid leukaemia.
- PersonZhu Chen
Shares Arsenic trioxide, Acute myeloid leukaemia.
- TechnologyBCL-2 inhibitors
Shares Chronic lymphocytic leukaemia, Acute myeloid leukaemia.
- TargetDNA polymerase alpha (POLA1)
Shares Ribonucleotide reductase (RRM1), Acute myeloid leukaemia.
- CompanyAscentage Pharma
Shares Chronic lymphocytic leukaemia, Acute myeloid leukaemia.
- TreatmentRasburicase
Shares Chronic lymphocytic leukaemia, Acute myeloid leukaemia.
- InstitutionRuijin Hospital, Shanghai Jiao Tong University
Shares Arsenic trioxide, Acute myeloid leukaemia.