ZHX2
ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
Overview
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
- 1 · What it is
ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
- 2 · What goes wrong in cancer
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
- 3 · How drugs use it
No product in this corpus aims at ZHX2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:18513 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6X8 (protein name, function text, keywords and locations (REST API)); CIViC gene ZHX2 (1 evidence items, 0 assertions, 1 variants; diseases: Papillary Renal Cell Carcinoma (GraphQL API, CC0))
Biology
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Location: Nucleus (UniProt). Locus 8q24.13 (HGNC).
- Papillary renal cell carcinoma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ZHX2" OR ABSTRACT:"ZHX2" OR TITLE:"zinc fingers and homeoboxes 2" OR ABSTRACT:"zinc fingers and homeoboxes 2" OR TITLE:"Zinc fingers and homeoboxes protein 2" OR ABSTRACT:"Zinc fingers and homeoboxes protein 2" OR TITLE:"KIAA0854" OR ABSTRACT:"KIAA0854") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZHX2, not a curated reading list.
Similar pages
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