Cancer cell line encyclopedias and dependency maps
Large public collections of cancer cell lines profiled for their genomes, drug sensitivity and gene dependencies, the reference data behind much of modern target discovery.
Overview
The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer project characterised about a thousand cell lines by sequencing, expression and drug response, and the Dependency Map (DepMap) added genome-wide CRISPR knockout screens that reveal which genes each line needs to survive. These resources identified synthetic lethal targets such as WRN in microsatellite-unstable cancers and PRMT5 in MTAP-deleted tumours, and they anchor machine-learning models of drug response.
How it works
Cell lines are profiled by sequencing and expression, treated with drug libraries, and screened with pooled CRISPR guides; dependencies emerge where knockout selectively kills lines with a given genotype.
- Open data used across academia and industry
- Systematic discovery of synthetic lethality
- Ground truth for predictive models
- Cell lines lack stroma and immune context
- Culture-adapted lines differ from tumours
- Limited representation of some cancers and ancestries
Latest papers
topQuery for this technology: (TITLE:"Cancer cell line encyclopedias and dependency maps" OR ABSTRACT:"Cancer cell line encyclopedias and dependency maps") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cancer cell line encyclopedias and dependency maps, not a curated reading list.
Similar pages
not linked directly; found by shared links- Key paperDefining a Cancer Dependency Map: which genes each cancer cell line cannot live without
Shares WRN helicase (MSI-high cancers), PRMT5 (MTAP-deleted cancers), Synthetic lethality approaches.
- IdeaA synthetic lethality map for every cancer driver in every tissue context
Shares Synthetic lethality approaches, Patient-derived organoids.
- PathwaySynthetic lethality: paired dependencies
Shares WRN helicase (MSI-high cancers), PRMT5 (MTAP-deleted cancers), Synthetic lethality approaches.
- TermSynthetic lethality
Shares WRN helicase (MSI-high cancers), PRMT5 (MTAP-deleted cancers), Synthetic lethality approaches.
- PathwayMismatch repair & microsatellite instability
Shares WRN helicase (MSI-high cancers), Synthetic lethality approaches.
- PathwayDrivers, passengers & the two-hit model
Shares PRMT5 (MTAP-deleted cancers), Synthetic lethality approaches.