Methylation classifier for brain tumours
A test that reads the methylation pattern of a brain tumour's DNA and matches it to a reference library, giving a more reliable diagnosis than the microscope alone.
Overview
Brain tumour diagnosis by microscopy is notoriously inconsistent. In 2018 the Heidelberg group published a machine-learning classifier that assigns tumours to one of more than eighty methylation classes from a genome-wide methylation array, reclassifying a meaningful share of cases and revealing new entities. The approach is now embedded in the WHO classification of central nervous system tumours and used in reference neuropathology centres.
How it works
DNA methylation is measured on an array, and a random-forest classifier trained on thousands of reference tumours returns the best-matching class with a calibrated score.
- Reproducible, objective diagnosis
- Detects rare and new entities
- Works on small or archived samples
- Array cost and turnaround
- Unclassifiable cases remain
- Requires reference-centre expertise
Latest papers
topQuery for this technology: (TITLE:"Methylation classifier for brain tumours" OR ABSTRACT:"Methylation classifier for brain tumours") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Methylation classifier for brain tumours, not a curated reading list.
Similar pages
not linked directly; found by shared links- PersonAndreas von Deimling
- PersonStefan Pfister
- PersonMonika E. Hegi
- TreatmentTovorafenib
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), Glioma & glioblastoma.
- TreatmentDordaviprone
Shares Brain and spinal cord tumours (all types), Glioma & glioblastoma.
- CancerEpendymoma
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), DNA methylation profiling.
- CancerDiffuse midline glioma, H3 K27-altered (including DIPG)
Shares Brain and spinal cord tumours (all types), Childhood cancers (all types), DNA methylation profiling, Glioma & glioblastoma.
- TermMGMT promoter methylation