Metabolic syndrome and insulin resistance
Metabolic syndrome is a cluster of central obesity, high blood pressure, high blood sugar and abnormal blood fats. It raises the risk of several cancers and worsens outcomes after diagnosis, largely through high insulin levels.
Insulin and IGF-1 are mitogenic and anti-apoptotic through the PI3K-AKT-mTOR pathway; hyperinsulinaemia also lowers sex-hormone-binding globulin, raising free oestrogen and androgen. Metabolic syndrome is associated with higher incidence of colorectal, liver, pancreatic, endometrial and postmenopausal breast cancer, and with recurrence in colon and breast cancer survivors. Metformin, despite strong epidemiology, failed to improve breast cancer outcomes in the MA.32 randomised trial, a caution about observational metabolic signals.
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not linked directly; found by shared links- IdeaLink bariatric and GLP-1 registries to cancer registries in every country that has both
Shares Bariatric surgery and cancer incidence, GLP-1 receptor agonists and obesity-related cancer risk, Obesity-related cancers (IARC list of 13), Endometrial cancer.
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Shares GLP-1 receptor agonists and obesity-related cancer risk, Endometrial cancer, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma.
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Shares Glycaemic index and glycaemic load, Energy balance, Lipid synthesis, uptake & cholesterol, Hepatocellular carcinoma.
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Shares Energy balance, Structured exercise programmes after curative treatment.
- IdeaA dose-finding trial for exercise after cancer
Shares Energy balance, Structured exercise programmes after curative treatment, Colorectal cancer.
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Shares Energy balance, PI3K / AKT / mTOR, Colorectal cancer.