A trial of GLP-1 weight-loss drugs with cancer as the primary outcome
Obesity raises the risk of 13 cancers. Weight-loss drugs are now widely used; a large trial should test whether they actually prevent cancer, not just diabetes and heart disease.
Observational data suggest GLP-1 receptor agonists reduce obesity-related cancer incidence, but confounding is severe. Propose an RCT, or prospective cancer adjudication embedded in ongoing cardiovascular outcome trials, with incident obesity-related cancer as the primary endpoint in adults aged 50-70 with BMI of 30 or more.
- Prevention we already have is not deployed · Around four in ten cancers are preventable with tools we already own: vaccines, tobacco control, weight, alcohol, sun and infection control.
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not linked directly; found by shared links- TechnologyBariatric surgery and cancer incidence
Shares Link bariatric and GLP-1 registries to cancer registries in every country that has both, GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Endometrial cancer.
- IdeaGLP-1 drugs to reverse endometrial precancer in women with obesity
Shares GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Endometrial cancer, Prevention we already have is not deployed.
- TermObesity-related cancers (IARC list of 13)
Shares GLP-1 receptor agonists as adjuvant weight-loss therapy in HR-positive breast cancer, Link bariatric and GLP-1 registries to cancer registries in every country that has both, GLP-1 receptor agonists and obesity-related cancer risk, Endometrial cancer.
- IdeaA delivery-science moonshot for prevention we already own
Shares IARC verdict: excess body fat causes 13 cancers, Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed, Hepatocellular carcinoma.
- TermMetabolic syndrome and insulin resistance
Shares GLP-1 receptor agonists and obesity-related cancer risk, Endometrial cancer, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma.
- ProductOlomorasib
Shares Eli Lilly (incl. Loxo), Pancreatic ductal adenocarcinoma, Colorectal cancer.
- InstitutionMUSC Hollings Cancer Center
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed, Colorectal cancer.
- InstitutionUniversity of Arizona Cancer Center
Shares Chemoprevention & risk-reducing surgery, Prevention we already have is not deployed, Colorectal cancer.