Obesity-related cancers (IARC list of 13)
Excess body fat is an established cause of at least thirteen cancers, including womb, oesophagus, kidney, liver, bowel, pancreas and postmenopausal breast cancer. It is the second largest preventable cause of cancer after smoking in many countries.
The IARC Handbook Working Group (2016) found sufficient evidence for cancers of the oesophagus (adenocarcinoma), gastric cardia, colon and rectum, liver, gallbladder, pancreas, postmenopausal breast, endometrium, ovary, kidney, meningioma, thyroid and multiple myeloma. Relative risks per 5 kg/m2 range from about 1.1 (breast) to 1.5-1.6 (endometrium, oesophageal adenocarcinoma). Mechanisms: insulin and IGF-1, sex hormones, adipokines and chronic inflammation. Population-attributable fractions are 4-8% of cancers in high-income countries and rising; bariatric surgery cohorts show the risk is at least partly reversible.
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not linked directly; found by shared links- Key paperIARC verdict: excess body fat causes 13 cancers
Shares International Agency for Research on Cancer (IARC / WHO), Thyroid cancer, Endometrial cancer, Prevention we already have is not deployed.
- IdeaA trial of GLP-1 weight-loss drugs with cancer as the primary outcome
Shares GLP-1 receptor agonists as adjuvant weight-loss therapy in HR-positive breast cancer, Link bariatric and GLP-1 registries to cancer registries in every country that has both, GLP-1 receptor agonists and obesity-related cancer risk, Endometrial cancer.
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Shares Ultra-processed food and sugar-sweetened drinks, Energy balance, Lipid synthesis, uptake & cholesterol, International Agency for Research on Cancer (IARC / WHO).
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Shares Ultra-processed food (NOVA group 4), Ultra-processed food and sugar-sweetened drinks, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed.
- TermAlcohol-attributable cancer
Shares Risk factor, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, Oesophageal cancer.
- TechnologyTime-restricted eating in cancer prevention and survivorship
Shares Metabolic syndrome and insulin resistance, Energy balance, Structured exercise programmes after curative treatment, Prevention we already have is not deployed.
- TermGlycaemic index and glycaemic load
Shares Ultra-processed food and sugar-sweetened drinks, Metabolic syndrome and insulin resistance, Energy balance, Endometrial cancer.
- IdeaControlled feeding trials to separate ultra-processing from calories
Shares Ultra-processed food (NOVA group 4), Ultra-processed food and sugar-sweetened drinks, Prevention we already have is not deployed, Colorectal cancer.