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MutSig asks which genes are mutated more often than the background mutation rate would predict, separating likely drivers from long or late-replicating genes that collect passengers.
Lawrence and colleagues showed that mutation rates vary enormously between patients and across the genome (with expression level and replication timing) and that ignoring this heterogeneity produces spurious driver genes; MutSigCV corrects for it using patient-specific rates and gene covariates. It became the standard driver test in TCGA marker papers alongside GISTIC for copy number. Like GISTIC it is distributed under a Broad research licence rather than an open repository.
Shares GISTIC (copy number driver detection), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Variant calling, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Variant calling, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Variant calling, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Driver mutation, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Variant calling, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.