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An actionable alteration is a change in a tumour's DNA that maps directly to an approved or investigational drug, so finding it changes what the patient is offered.
Precision or personalised medicine tailors decisions to the patient's predicted response based on molecular features (Wikipedia). In oncology a genomic alteration is called actionable when an approved drug, a guideline recommendation or an open trial is tied to it; OncoKB and CIViC grade the evidence in tiers. Actionability is narrower than being a driver: many drivers have no drug, and some drug targets (HER2 amplification) are actionable regardless of driver status.
Showing the technology this term belongs to: Comprehensive genomic profiling.
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Shares Biomarker, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Biomarker, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map), CIViC and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.