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A targeted panel sequences only a chosen set of a few hundred cancer genes, deeply and cheaply, which is what most hospitals run on tumours today.
Exome sequencing works by selecting a subset of DNA before sequencing (Wikipedia); a targeted panel narrows the selection further to hundreds of clinically relevant genes, read at high depth from small samples. Panels such as MSK-IMPACT and FoundationOne underlie AACR Project GENIE, the largest clinico-genomic dataset, but panel coverage differs between institutions, so pooling requires restricting to shared genes and treating unsequenced genes as missing rather than wild type.
Showing the technology this term belongs to: Comprehensive genomic profiling.
Shares Actionable genomic biomarkers, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares AACR Project GENIE, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Somatic mutations from exome and genome sequencing (WXS, WGS), Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.