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Drug sensitivity is how strongly a tumour or cell line is held back by a compound; it is summarised by the concentration that halves growth (IC50) or by the area under the whole dose-response curve.
The half maximal inhibitory concentration, IC50, measures the potency of a substance in inhibiting a biological function, the amount needed to inhibit a process by half in vitro (Wikipedia). Cell-line screens such as GDSC and CTRP report IC50, GI50 and the area under (or above) the dose-response curve for hundreds of drugs across hundreds of lines. The readouts are not interchangeable: different viability assays (CellTiter-Glo versus Syto60) and different summary statistics are a known source of disagreement between datasets.
Shares Drug-response data splits: leave-cell-line-out, leave-drug-out, leave-tissue-out, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Pharmacogenomics, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cell lines as a proxy for patients, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Drug-response data splits: leave-cell-line-out, leave-drug-out, leave-tissue-out, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Drug-response data splits: leave-cell-line-out, leave-drug-out, leave-tissue-out, Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.
Shares Cancer AI vocabulary (CanSim terms map) and the tag cansim-terms.