collectionsCollection

DepMap (Cancer Dependency Map)

Which genes each cancer cell line cannot live without. The map of synthetic-lethal targets.

Chronos gene-effect scores, PRISM drug sensitivity, CCLE omics; quarterly releases.

URL

Holds

Genome-wide CRISPR and drug screens across >1,000 cancer cell lines with multi-omics.

Licence

CC BY 4.0

Maintainer

Broad Institute

Key papers

Defining a Cancer Dependency Map: which genes each cancer cell line cannot live without

DepMap is the lookup table drug hunters use to ask: which cancers would die if we blocked this gene, and how would we recognise them? It generated targets such as WRN and PRMT5-MTAP now in clinical trials, and it is public.

Connected

technologies

2

CRISPR functional genomics Synthetic lethality approaches

institutions

2

Broad Institute of MIT and Harvard Wellcome Sanger Institute

roadmaps

1

Virtual cell roadmap: from bulk omics to a predictive model of a cancer cell

ideas

9

A drug screen that only rewards killing sleeping cancer cells A pre-competitive consortium to validate or kill academic targets before licensing A public atlas of drug-pair responses across a thousand patient-derived organoids An open engine that ranks every drug pair by predicted synergy before anyone runs a trial An open foundation model of the cancer cell trained on perturbation data An open model bank for the rare tumours nobody has models for Every drug screen includes standard reference compounds whose performance is published Group trials by broken mechanism, not by organ or single mutation Make in vivo metastasis screens a required step in drug discovery

bottlenecks

5

Preclinical models that do not predict people Preclinical results do not reproduce The undruggable drivers The valley of death between lab and product Too many combinations to test

key papers

1

Defining a Cancer Dependency Map: which genes each cancer cell line cannot live without