termsTerm
Variant of uncertain significance (VUS)
A variant of uncertain significance (VUS) is a genetic change that has been found but nobody yet knows whether it matters.
Common in germline panels (up to 30% of reports) and tumour sequencing. Should not drive treatment decisions; reclassified over time via ClinVar, functional assays, and population data.
Genomics: what this kind of term is about · animated schematic, not to scale
Category
Genomics