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AVIATOR compares trastuzumab and vinorelbine with combinations that add avelumab, with or without utomilumab. It asks whether the added immune treatments improve control of advanced HER2-positive breast cancer.
AVIATOR compares trastuzumab and vinorelbine with combinations that add avelumab, with or without utomilumab. It asks whether the added immune treatments improve control of advanced HER2-positive breast cancer.
Interventional study registered as NCT03414658, sponsored by Adrienne G. Waks. Registry phase: 2. Registry enrollment is 100 participants (actual). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.
The full inclusion and exclusion criteria are on the registry record. Read 2026-10-10. Recruiting overall does not mean a particular site is open; ask the study team.
ClinicalTrials.gov data courtesy of the US National Library of Medicine.
Shares Utomilumab, Avelumab, UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Trastuzumab, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Trastuzumab, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
Shares UCSF Helen Diller Family Comprehensive Cancer Center, Breast cancer (all types) and the tags ucsf-breast-coverage, interventional.
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