Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)

Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study) is a phase 3, randomised interventional study registered as NCT06450574 by Corporacion Parc Tauli, with a registry enrolment figure of 106 participants, started 2024-10 and due to reach its primary completion in 2026-10. Interventions recorded: Capecitabine (Xeloda); 50.4 Gy; Transanal Endoscopic Microsurgery (TEM); Transanal Endoscopic Microsurgery. Conditions listed: Rectal Cancer Stage I. Primary outcome: Rectal preservation in T1,N0,M0 rectal cancer; Total mesorectal excision in T1,N0,M0 rectal cancer. Colorectal eligibility wording from the registry: "* Rectal adenocarcinomas in the biopsy, located at a distance from the anal margin less than or equal to 10 cm measured by rigid rectoscopy at the time of ER". No results are recorded here; the registry entry is the source.