A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT06919510 by Sun Yat-sen University, with a registry enrolment figure of 90 participants, started 2025-04-01 and due to reach its primary completion in 2026-06-01. Interventions recorded: lvonescimab; CAPOX (oxaliplatin/capecitabine); radiotherapy; Surgery or watch&wait. Conditions listed: Rectal Adenocarcinoma. Primary outcome: Adverse events; Complete response rate; Clinical complete response rate. Colorectal eligibility wording from the registry: "Histologically proven rectal adenocarcinoma;". No results are recorded here; the registry entry is the source.