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A phase 3 trial of capecitabine, fluorouracil (5-FU), gemcitabine, irinotecan (and liposomal irinotecan) and other drugs in pancreatic cancer, run by NRG Oncology, now recruiting.
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer is a phase 3, randomised interventional study registered as NCT06958328 by NRG Oncology, with a registry enrolment figure of 356 participants, started 2025-08-21 and due to reach its primary completion in 2030-10-21. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Capecitabine; Computed Tomography; Dose-escalated Radiation Therapy; Fluorouracil; Gemcitabine; Irinotecan Hydrochloride; Irinotecan Sucrosofate; Leucovorin Calcium; Magnetic Resonance Imaging; Nab-paclitaxel; Observation Activity; Oxaliplatin; Positron Emission Tomography; Questionnaire Administration; Radiation Therapy; Tumor Treating Fields Therapy. Conditions listed: Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8. Primary outcome: Overall survival (OS). Pancreatic eligibility wording from the registry: "* Pathologically (histologically or cytologically) proven diagnosis of pancreatic ductal adenocarcinoma". Sites: Canada, United States. No results are recorded here; the registry entry is the source.
Shares Irinotecan (and liposomal irinotecan), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Locally advanced unresectable pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Topoisomerase-I inhibitors (and ADC payloads), Capecitabine and the tag pancreatic-deep-dive.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Nab-paclitaxel, Fluorouracil (5-FU) and the tag pancreatic-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Nab-paclitaxel, Fluorouracil (5-FU), Locally advanced unresectable pancreatic ductal adenocarcinoma and the tag pancreatic-deep-dive.
Shares Nab-paclitaxel, Fluorouracil (5-FU), Locally advanced unresectable pancreatic ductal adenocarcinoma, Topoisomerase-I inhibitors (and ADC payloads) and the tag pancreatic-deep-dive.
Shares Leucovorin (folinic acid), CAPOX (capecitabine, oxaliplatin), Fluorouracil (5-FU), Topoisomerase-I inhibitors (and ADC payloads) and the tag pancreatic-deep-dive.
Shares CAPOX (capecitabine, oxaliplatin), Nab-paclitaxel, Fluorouracil (5-FU), Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.
Shares Nab-paclitaxel, Locally advanced unresectable pancreatic ductal adenocarcinoma, Capecitabine, Pancreatic cancer trials open today (registry snapshot and UK sites) and the tag pancreatic-deep-dive.