Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized,

Node-Sparing Hypofractionated Radiotherapy Plus Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Randomized, Phase II Trial is a phase 2, randomised interventional study registered as NCT07230639 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 52 participants, started 2025-08-30 and due to reach its primary completion in 2030-08-29. Interventions recorded: Node-Sparing Radiotherapy(25Gy/5F) plus Chemotherapy and PD-1 inhibitor; Node-Sparing Radiotherapy(24Gy/4F) plus Chemotherapy and PD-1 inhibitor. Conditions listed: Neoadjuvant Therapies; Immune Checkpoint Therapy; Radiotherapy. Primary outcome: Pathological Complete Response(pCR) Rate. Colorectal eligibility wording from the registry: "Histologically confirmed colon adenocarcinoma (without squamous or sarcomatoid components)". Sites: China. No results are recorded here; the registry entry is the source.