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A phase 2 trial of botensilimab and balstilimab in colorectal cancer, run by Dana-Farber Cancer Institute, now recruiting.
RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer is a phase 2, interventional study registered as NCT07735624 by Dana-Farber Cancer Institute, with a registry enrolment figure of 16 participants, started 2026-09 and due to reach its primary completion in 2027-01-01. Interventions recorded: Botensilimab; Balstilimab. Conditions listed: Early Rectal Cancer; Stage I Rectal Cancer; Microsatellite Stable Rectal Carcinoma. Primary outcome: Complete response (cCR plus nCR with pCR at resection) within 6 months from initiation of therapy or nCR with pathologic complete response (pCR) with TES. Colorectal eligibility wording from the registry: "* Histologically confirmed diagnosis of early-rectal cancer clinically staged T1-T2 N0 M0 by MRI (American Joint Committee on Cancer (AJCC) staging 8th edition, 2017)". Sites: United States. No results are recorded here; the registry entry is the source.
Shares Agenus, Botensilimab, Balstilimab, Mismatch-repair deficient (MSI-high) colorectal cancer and the tag colorectal-deep-dive.
Shares Agenus, Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Agenus, Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot) and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Botensilimab, Balstilimab, Colorectal cancer trials open today (registry snapshot), Rectal cancer and the tag colorectal-deep-dive.
Shares Mismatch-repair deficient (MSI-high) colorectal cancer, Colorectal cancer trials open today (registry snapshot), Rectal cancer, Immune checkpoint inhibitors and the tag colorectal-deep-dive.